Mapk8 ELISA Kit for Mouse(Mus musculus) | EIAab.comMapk8 ELISA Kit for Mouse(Mus musculus)

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Mapk8 (Gene name),

Mitogen-activated protein kinase 8 (Protein name ), MK08_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Mapk8(Jnk1;Prkm8);

Protein name:

Mitogen-activated protein kinase 8(MAP kinase 8;MAPK 8);

Alternative:

c-Jun N-terminal kinase 1;Stress-activated protein kinase JNK1;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Binds to at least four scaffolding proteins, MAPK8IP1/JIP-1, MAPK8IP2/JIP-2, MAPK8IP3/JIP-3/JSAP1 and SPAG9/MAPK8IP4/JIP-4. These proteins also bind other components of the JNK signaling pathway. Forms a complex with MAPK8IP1 and RGNEF. Interacts with TP53 and WWOX. Interacts with JAMP. Interacts with NFATC4. Interacts with MECOM; regulates JNK signaling (By similarity). Interacts (phosphorylated form) with NFE2; the interaction phosphorylates NFE2 in undifferentiated cells.

Function:

Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as JUN, JDP2 and ATF2 and thus regulates AP-1 transcriptional activity. In T-cells, JNK1 and JNK2 are required for polarized differentiation of T-helper cells into Th1 cells. Phosphorylates heat shock factor protein 4 (HSF4).

Subcellular Location:

N/A

Protein Attributes:

Sequence length:

384

Sequence:

50:

100:

150:

200:

250:

300:

350:

384:

EWKELIYKEV | MDLEERTKNG | VIRGQPSPLA | QVQQ

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

Q91Y86

UniGene:

Mm.21495

KEGG:

mmu:26419

Pfam:

PF00069

String:

Q91Y86

STRING:

10090.ENSMUSP00000022504

Uniprot:

Q91Y86

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ELISA Kit for Mouse MAP kinase 8

Cat.:

E9092m

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96T

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ELISA Kit for Mouse MAP kinase 8

Cat.:

E9092r

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96T

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ELISA Kit for Mouse MAP kinase 8

Cat.:

E9092h

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96T

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CLIA Kit for Mouse MAP kinase 8

Cat.:

U9092h

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Packing:

96T

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CLIA Kit for Mouse MAP kinase 8

Cat.:

U9092r

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Mouse MAP kinase 8

Cat.:

U9092m

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MSDS:

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Packing:

96T

Polyclonal Antibody for Mouse MAP kinase 8

Cat.:

P9092Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse MAP kinase 8

Cat.:

P9092Rb-h

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Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse MAP kinase 8

Monoclonal Antibody for Mouse MAP kinase 8

Protein for Mouse MAP kinase 8

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

"JSAP1, a novel jun N-terminal protein kinase (JNK)-binding protein that functions as a scaffold factor in the JNK signaling pathway."
Ito M. , Yoshioka K. , Akechi M. , Yamashita S. , Takamatsu N. , Sugiyama K. , Hibi M. , Nakabeppu Y. , Shiba T. , Yamamoto K.
Mol. Cell. Biol.19:7539-7548(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];INTERACTION WITH MAPK8IP3
tissue: Brain.
2.

"JNK1, JNK2 and JNK3 are p53 N-terminal serine 34 kinases."
Hu M.C. , Qiu W.R. , Wang Y.P.
Oncogene15:2277-2287(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF TP53
3.

"Targeted disruption of the MKK4 gene causes embryonic death, inhibition of c-Jun NH2-terminal kinase activation, and defects in AP-1 transcriptional activity."
Yang D. , Tournier C. , Wysk M. , Lu H.-T. , Xu J. , Davis R.J. , Flavell R.A.
Proc. Natl. Acad. Sci. U.S.A.94:3004-3009(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REGULATION BY MAP2K4
tissue: Embryonic stem cell.
4.

"Mitogen-activated protein kinase kinase 7 is an activator of the c-Jun NH2-terminal kinase."
Tournier C. , Whitmarsh A.J. , Cavanagh J. , Barrett T. , Davis R.J.
Proc. Natl. Acad. Sci. U.S.A.94:7337-7342(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REGULATION BY MAP2K7;COFACTOR
5.

"JNK is required for effector T-cell function but not for T-cell activation."
Dong C. , Yang D.D. , Tournier C. , Whitmarsh A.J. , Xu J. , Davis R.J. , Flavell R.A.
Nature405:91-94(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;ENZYME REGULATION;INDUCTION
tissue: Embryonic stem cell.
tissue: T-cell.
6.

"The AP-1 repressor, JDP2, is a bona fide substrate for the c-Jun N-terminal kinase."
Katz S. , Heinrich R. , Aronheim A.
FEBS Lett.506:196-200(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF JDP2
7.

"Requirement of the JIP1 scaffold protein for stress-induced JNK activation."
Whitmarsh A.J. , Kuan C.-Y. , Kennedy N.J. , Kelkar N. , Haydar T.F. , Mordes J.P. , Appel M. , Rossini A.A. , Jones S.N. , Flavell R.A. , Rakic P. , Davis R.J.
Genes Dev.15:2421-2432(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBUNIT;PHOSPHORYLATION AT THR-183 AND TYR-185
tissue: Hippocampus.
8.

"JLP: a scaffolding protein that tethers JNK/p38MAPK signaling modules and transcription factors."
Lee C.M. , Onesime D. , Reddy C.D. , Dhanasekaran N. , Reddy E.P.
Proc. Natl. Acad. Sci. U.S.A.99:14189-14194(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SPAG9
9.

"Cytoplasmic retention sites in p190RhoGEF confer anti-apoptotic activity to an EGFP-tagged protein."
Wu J. , Zhai J. , Lin H. , Nie Z. , Ge W.-W. , Garcia-Bermejo L. , Muschel R.J. , Schlaepfer W.W. , Canete-Soler R.
Brain Res. Mol. Brain Res.117:27-38(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN A COMPLEX WITH MAPK8IP1 AND ARHGEF28
10.

"Phosphoproteomic analysis of the developing mouse brain."
Ballif B.A. , Villen J. , Beausoleil S.A. , Schwartz D. , Gygi S.P.
Mol. Cell. Proteomics3:1093-1101(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-377;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Embryonic brain.
11.

"JAMP, a Jun N-terminal kinase 1 (JNK1)-associated membrane protein, regulates duration of JNK activity."
Kadoya T. , Khurana A. , Tcherpakov M. , Bromberg K.D. , Didier C. , Broday L. , Asahara T. , Bhoumik A. , Ronai Z.
Mol. Cell. Biol.25:8619-8630(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH JAMP
12.

"JNK1 phosphorylation of SCG10 determines microtubule dynamics and axodendritic length."
Tararuk T. , Ostman N. , Li W. , Bjorkblom B. , Padzik A. , Zdrojewska J. , Hongisto V. , Herdegen T. , Konopka W. , Courtney M.J. , Coffey E.T.
J. Cell Biol.173:265-277(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;DEVELOPMENTAL STAGE
13.

"JNK-mediated turnover and stabilization of the transcription factor p45/NF-E2 during differentiation of murine erythroleukemia cells."
Lee T.L. , Shyu Y.C. , Hsu P.H. , Chang C.W. , Wen S.C. , Hsiao W.Y. , Tsai M.D. , Shen C.K.
Proc. Natl. Acad. Sci. U.S.A.107:52-57(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NFE2;FUNCTION
14.

"Phosphorylation of SCG10/stathmin-2 determines multipolar stage exit and neuronal migration rate."
Westerlund N. , Zdrojewska J. , Padzik A. , Komulainen E. , Bjorkblom B. , Rannikko E. , Tararuk T. , Garcia-Frigola C. , Sandholm J. , Nguyen L. , Kallunki T. , Courtney M.J. , Coffey E.T.
Nat. Neurosci.14:305-313(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DISRUPTION PHENOTYPE

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